INTEGRATED SENSORS, LLC - Florida Company Profile

isensors.net

419-536-3212

peter@isensors.net

419-536-3212

PETER FRIEDMAN

P0706577

3VMP8

Active

Non-Manufacturer

2025-01-16

2030-01-16

2026-01-14

PETER FRIEDMAN

isensors.net

2022-07-18

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Department of Health and Human Services

ULTRAFAST AND PRECISE EXTERNAL BEAM MONITOR FOR FLASH AND OTHER ADVANCED RADIATION THERAPY MODALITIES - SUMMARY/ABSTRACT FLASH RADIOTHERAPY (FLASH-RT) IS A NOVEL FORM OF RADIATION THERAPY THAT PROMISES LARGE SPARING OF NORMAL- TISSUES IN CANCER TREATMENT WHILE SHOWING NO TUMOR SPARING. IN FLASH-RT, THE RADIATION DOSE IS DELIVERED TO THE TUMOR AND NORMAL TISSUES IN MILLISECONDS RATHER THAN MINUTES. FLASH-RT IS ONLY EFFECTIVE WHEN GIVEN WITH LARGE DOSES PER FRACTION DELIVERED IN 1-3 TREATMENT SESSIONS. IT WOULD SHORTEN A STANDARD 30-DAY TREATMENT TO 1- 3 DAYS, THUS GREATLY REDUCING SIDE-EFFECTS AND RADIATION THERAPY COSTS TO BOTH THE PATIENT AND SOCIETY. THE FIRST HUMAN PATIENT WAS SUCCESSFULLY TREATED IN 2018. THE FIRST CLINICAL TRIAL WITH TEN (10) PATIENTS STARTED IN THE U.S. IN NOVEMBER 2020. ADDITIONAL CLINICAL TRIALS ARE PLANNED FOR 2021 IN THE U.S. AND IN EUROPE WITH AT LEAST 100 PATIENTS. A MAJOR LIMITATION OF FLASH-RT, PREVENTING A FAST TRANSLATION TO CLINICAL USE, IS THE LACK OF DETECTORS CAPABLE OF MEETING THE REQUIREMENTS NEEDED TO MONITOR AND TERMINATE THE FLASH-RT TREATMENT IN REAL TIME. WE PROPOSE TO DEVELOP AND DEMONSTRATE A LARGE AREA, ULTRAFAST AND PRECISE EXTERNAL BEAM MONITOR FOR FLASH-RT, UNIVERSALLY SUITABLE FOR ELECTRONS, PROTONS, PHOTONS, AND IONS, THAT CAN TERMINATE THE BEAM IN =1 MS WHILE THE PATIENT IS BEING TREATED. FOR THIS PROPOSAL, WE WILL PRIMARILY FOCUS ON DEVELOPING AND DEMONSTRATING THE SYSTEM FOR ELECTRON FLASH-RT WITH LINACS AND PROTON FLASH-RT WITH EXISTING CYCLOTRONS, BUT WILL ALSO DEMONSTRATE PERFORMANCE USING X-RAYS. UNLIKE STRIP OR WIRE IONIZATION CHAMBERS, THE PROPOSED SYSTEM IS BASED ON OUR PATENTED (JAN 2020 AND NOV 2020) IONIZING-RADIATION BEAM MONITORING SYSTEM TECHNOLOGY, WHICH CAN PROVIDE ULTRAFAST READOUT WITH CONCURRENT ANALYSIS OF THE RADIATION BEAM POSITION, PROFILE, AND FLUENCE/DOSIMETRY IN REAL TIME AT A RATE OF =10 KHZ (I.E., BEAM ANALYSIS =100 ΜS). THE PROPOSED SYSTEM PROVIDES REAL-TIME DOSIMETRY, BEAM CONTROL, AND VERIFICATION FOR FLASH-RT. IT PROVIDES AN ACCURATE 2D POSITION AND BEAM PROFILE OF RAPIDLY SCANNED BEAMS WITH A SPATIAL RESOLUTION OF A FEW MICRONS OVER AN ACTIVE BEAM MONITORING AREA OF 26 CM X 30 CM. THE BEAM MONITOR RESPONSE IS LINEAR, WITHOUT SATURATION, FOR ALL FLASH-RT BEAM LUMINOSITIES. PROTON BEAM TESTING WILL BE PRIMARILY AT THE UNIVERSITY OF MICHIGAN ION BEAM LABORATORY, AND ELECTRON BEAM TESTING AT THE NOTRE DAME RADIATION LABORATORY. THE PROPOSED PROGRAM IS FOR 3-YEARS AND WILL EVOLVE FROM FABRICATION AND TESTING OF A QUARTER-SCALE BEAM MONITOR IN YEAR 1 TO A FULL-SIZE SYSTEM WITH SELF-CALIBRATION CAPABILITY IN YEAR 3. OUR PRINCIPAL COLLABORATORS ON THIS PROGRAM INCLUDE THE UNIVERSITY OF MICHIGAN, PHYSICS DEPARTMENT, AND LOMA LINDA UNIVERSITY, SCHOOL OF MEDICINE. THE PROPOSED BEAM MONITOR CONSTITUTES A CRITICAL ENABLING TECHNOLOGY FOR ALL TYPES OF FLASH-RT. IT WILL ENSURE THE SAFETY, QUALITY, AND EFFICIENCY OF FLASH RADIATION THERAPY, ALLOWING CANCER PATIENTS TO BE SUCCESSFULLY TREATED WITH MUCH HIGHER DOSES, FEWER SIDE-EFFECTS, AND EXCELLENT TUMOR CONTROL. IT IS ALSO SUITABLE FOR SPATIALLY FRACTIONATED RADIATION THERAPY TECHNIQUES SUCH AS GRID, LATTICE, MICROBEAM RT (MRT), AND PROTON-MINIBEAM RT (PMBRT). THE PROPOSED BEAM MONITOR IS ALSO BEING DESIGNED INTO A NOVEL (PATENT PENDING) ULTRAFAST RADIOABLATION SYSTEM THAT ELIMINATES THE MOTION PROBLEM FOR TREATING CARDIAC ARRHYTHMIA (AFIB). OMB NO. 0925-0001/0002 (REV. 01/18 APPROVED THROUGH 03/31/2020) PAGE CONTINUATION FORMAT PAGE

1887301.00

0.00

0.00

2023-04-05

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Department of Energy

HIGH PERFORMANCE SCINTILLATOR AND BEAM MONITORING SYSTEM

1716938.00

0.00

0.00

2021-03-03

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Department of Health and Human Services

LARGE-AREA PLASMA PANEL DETECTORS FOR PARTICLE BEAM RADIATION THERAPY - DESCRIPTION (PROVIDED BY APPLICANT): A JOINT DOE-NCI WORKSHOP ON ION BEAM THERAPY (JANUARY 2013, BETHESDA, MD) IDENTIFIED AN AMBITIOUS SET OF TECHNOLOGY DEVELOPMENTS NEEDED TO SUPPORT A WORLD-CLASS TREATMENT PROGRAM FOR ION BEAM THERAPY. ONE IMPORTANT REQUIREMENT IS THE ABILITY TO PROVIDE DETECTORS THAT AFFORD SINGLE-PARTICLE REGISTRATION AT HIGH DATA RATES WITH HGH DEGREE OF UNIFORMITY AND MINIMAL INTERFERENCE WITH THE PARTICLE BEAM. THIS WOULD ALLOW PERFORMING PROTON OR ION CT PRIOR TO TREATMENT AND 2D PROTON/ION RADIOGRAPHY DURING TREATMENT FOR INTEGRATED RANGE VERIFICATION, ALONG WITH BEAM DIAGNOSTICS THAT HAVE MINIMAL INTERFERENCE WITH THE PRIMARY BEAM. CURRENT SILICON DETECTORS EMPLOYED IN FIRST DEVELOPMENTS OF PROTON IMAGING SYSTEMS HAVE MAJOR LIMITATIONS IN TERMS OF MAXIMUM AVAILABLE DETECTOR SIZE. LIMITATIONS ALSO EXIST FOR CURRENTLY USED BEAM MONITORING DETECTORS THAT ARE NOT SUITABLE FOR VERY FAST RESPONSE TIMES AT HIGH BEAM INTENSITIES REQUIRED FOR FUTURE CLINICAL APPLICATIONS OF PARTICLE BEAM SCANNING. WE PROPOSE TO DEVELOP A NOVEL DETECTOR, THE PLASMA PANEL SENSOR (PPS), THAT HAS THE POTENTIAL TO REMOVE ALL THE BARRIERS OF EXISTING DETECTORS AND SHOULD THEREFORE ALLOW PARTICLE BEAM RADIATION THERAPY TO REALIZE ITS FULLEST POTENTIAL TO BE USED IN FUTURE CLINICAL PARTICLE BEAM THERAPY CENTERS. FUNDAMENTALLY THE PROPOSED DETECTORS SHOULD BE INHERENTLY UNIFORM AND OF LOW MASS WITH FAST RESPONSE TIME. DURING PHASE I WE WERE SUCCESSFUL MANUFACTURING ULTRATHIN-PPS GLASS SUBSTRATES (I.E., 0.30, 0.20 AND 0.026 MM THICKNESS) WITH ELECTRODE PITCHES OF 2.54 MM AND 0.35 MM, CORRESPONDING TO THEORETICAL SPATIAL RESOLUTIONS OF ~ 0.73 MM AND 0.10 MM, RESPECTIVELY, AS DEMONSTRATED WITH GEANT4 MONTE CARLO SIMULATIONS. SUB-MILLIMETER IMAGE RESOLUTION THUS SEEMS EMINENTLY ACHIEVABLE, AND WHEN COMBINED WITH POTENTIALLY HIGH PARTICLE DETECTION EFFICIENCIES COULD MAKE THESE DETECTORS THE TECHNOLOGY OF CHOICE FOR BOTH IMAGING AND BEAM MONITORING SENSORS IN THE PARTICLE THERAPY TREATMENT ROOM. IN THIS 36-MONTH PHASE II SBIR WE PROPOSE TO: (1) FABRICATE AND TEST ON A CLINICAL BEAM LINE A SERIES OF PROGRESSIVELY LARGER AND HIGHER RESOLUTION, ULTRATHIN-PPS DEVICES WITH 2D READOUT; (2) DEVELOP GEANT4 MONTE CARLO SIMULATION MODELS OF THE DETECTOR PROTOTYPES TO ASSIST IN DATA ANALYSIS, DEVICE DESIGN REFINEMENT, AND PERFORMANCE OPTIMIZATION; AND (3) DEMONSTRATE THAT THE ULTRATHIN-PPS DEVICES WILL MEET THE CLINICAL REQUIREMENTS AS SUMMARIZED IN OUR PHASE-I FINAL REPORT. MEETING THE TARGET OBJECTIVES OF THIS SBIR PHASE II WILL ENABLE INTEGRATED SENSORS TO GENERATE THE PHASE III FUNDS TO PRODUCE A UNIVERSAL DETECTOR SYSTEM THAT WILL IMPROVE BOTH TREATMENT EFFICACY AND THE SAFETY OF PARTICLE BEAM THERAPY WITH PROTONS AND IONS.

1893362.00

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